منابع مشابه
Tumor suppressors: enhancers or suppressors of regeneration?
Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essentia...
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I have a sweet tooth, and I will always choose any pastry over spinach salad. I also know that many readers will share this preference. However, I am also aware that an unbalanced diet, in quantity and quality, is associated with serious health problems, including type 2 diabetes, metabolic syndrome, cardiovascular diseases, and cancer. It has therefore become a pressing question in basic and t...
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Haploids bearing the dominant UAG suppressor, SUP7-a, and various alleles of the omnipotent suppressor sup35 were examined. The presence of the UAG suppressor reduced the efficiency of some alleles of sup35, and caused other sup35 alleles to be lethal. A nonclassical interaction of the dominant suppressor tRNA and the ribosome is proposed to explain these observations.
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Acknowledgements Authors are indebted to Dr. Diana Quiñones Tapia for expert neuroradiological assistance during the human studies and to Mr. Javier Pérez CSIC, for careful, professional drafting of the illustrations. Abstract Hypothalamic appetite regulation is a vital homeostatic process underlying global energy balance in animals and humans, its disturbances resulting in feeding disorders wi...
متن کاملNovel nematode amber suppressors.
Nine amber suppressor mutations were isolated in the nematode Caenorhabditis elegans by reverting amber alleles of a sex-determining gene, tra-3. One suppressor maps to a known locus, sup-5 III , but the other eight map to three new loci, sup-21 X (five alleles), sup-22 IV (two alleles) and sup-23 IV (one allele). Amber alleles of tra-3 and of a dumpy gene, dpy-20, were used to measure the effi...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2017
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn.2017.86